Physicians at four European universities have completed what they say is the first successful transplant of a human windpipe using a patient’s own stem cells to fashion an organ and prevent its rejection by her immune system.
From CNN:
Doctors have given a woman a new windpipe with tissue engineered from her own stem cells in what experts have hailed as a “milestone in medicine.”
The breakthrough allowed Claudia Castillo, 30, to receive a new section of trachea — an airway essential for breathing — without the risk that her body would reject the transplant.
Castillo was given the stem cell surgery, the controversial branch of medicine that some say could lead to human cloning, after suffering a severe lung collapse.
The condition, caused by long-term tuberculosis left Castillo, a Colombian now living in Barcelona, unable to carry out simple domestic duties or care for her two children.
The only conventional option was a major operation to remove her left lung, a risky procedure with a high mortality rate.
From the New York Times:
The transplant operation was performed on the patient, Claudia Castillo, in June in Barcelona, Spain, to alleviate an acute shortage of breath caused by a failing airway following severe tuberculosis. It followed weeks of preparation carried out at the universities of Barcelona, Spain, Bristol, England and Padua and Milan in Italy.
News of the procedure coincided with speculation that President-elect Barack Obama may reverse the Bush Administration’s restrictions on stem cell research, which has been contentious in some European countries, too. Anthony Hollander, a professor at Bristol University, said ethical concerns relating to embryonic stem cell research had not surfaced in the latest procedure because it had used only the patient’s own stem cells. “This was not embryonic stem cell research,” he said in a telephone interview.
Ms. Castillo, 30, was hospitalized in March with her windpipe so badly damaged by tuberculosis that she was unable to walk more than a few steps at a time, according to a statement from Bristol University.
“The only conventional option remaining was a major operation to remove her left lung which carries a risk of complications and a high mortality rate,” Bristol University said.
The surgery represented what the university called “pioneering work.”
“We are terribly excited by these results,” said Prof. Paolo Macchiarini of the University of Barcelona, who performed the operation. “Just four days after transplantation the graft was almost indistinguishable from adjacent normal bronchi.”
